Pdf largest mucoepidermoid carcinoma of parotid gland in the. For this patient, there is no medical history of head and neck tumors, so the probability of metastatic scc was ruled out. Ask the experts mucoepidermoid carcinoma of the parotid. Diagnosis and management of malignant salivary gland tumors of the. Skin nonmelanocytic tumors mucoepidermoid carcinoma. Parotid gland is the most frequently involved major salivary gland half of all cases. Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain com. The purpose of this study was to examine how patient demographics and tumor characteristics affect overall survival.
Mucoepidermoid carcinoma mec of the salivary gland is believed to arise from pluripotent reserve cells of the excretory ducts that are capable of differentiating into squamous, columnar, and mucous cells. The majority 75% of salivary gland tumors occur in the parotid gland, and while benign lesions are more common, mucoepidermoid carcinoma mec makes up 4050% of malignant parotid gland tumors. The rareness of salivary gland tumors is particularly true for the malignant parotid tumors which are more frequent in juvenile patients, a fact that has to be considered in diagnosis and therapy. Proliferating cell nuclear antigen expression in mucoepidermoid. Mec mainly occurs in the parotid gland, along with minor glands being the second common site, particularly in palate. Objective to determine clinical and histopathologic features of mucoepidermoid carcinoma of the parotid gland, specifically, the relation of tumor stage and grade and treatment type with clinical outcome. Adjuvant treatment for parotid mucoepidermoid carcinoma.
Mucoepidermoid carcinoma of the parotid radiology case. It affects chiefly the parotid, but also other major and minor salivary glands. Parotidectomy mucoepidermoid carcinoma close margins radiotherapy. Introduction pulmonary mucoepidermoid carcinoma pmec is an uncommon neoplasm of the lung and the main salivary glandtype lung carcinoma.
Mucoepidermoid carcinoma mec is the most common primary salivary gland malignancy, accounting for approximately 25% of all malignancies. Recurrent mucoepidermoid carcinoma of parotid with facial tics report of an unusual case published. These tumors grow slowly and present as painless masses in most cases. Warthin tumor, and mucoepidermoid carcinoma are commonly found in the parotid glands whereas polymorphous low. Patients from 1940 to 1994, 128 patients were treated at our institution for parotid mucoepidermoid carcinoma. This is a case of a young boy with lowgrade mucoepidermoid carcinoma treated with superficial parotidectomy, resulting in positive margins. I had a mucoepidermoid carcinoma of the parotid at age 17 in 1978. Patients with unresectable and metastatic mec have poor longterm clinical outcomes, and no targeted therapy is currently available. Mucoepidermoid carcinoma mec is the most common salivary gland cancer in both.
The most common benign parotid tumor is pleomorphic adenoma, and the most common malignant parotid tumor is mucoepidermoid carcinoma table 563. The role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland. In contrast to sdc, mec is observed over a wider age range, has a female or less striking male predominance, and occurs in major and minor salivary glands with approximately equal frequency 34 38. I did have an unrelated tumor type on my left clavicle at age 20, but have been cancerfree since 1981. Their pattern of incidence differs very much from that of adults.
Background prognostic factors for parotid mucoepidermoid carcinoma mec usually include disease grade, tumor stage, node stage. Mec can also involve a variety of other sites that have minor mucoserous glands. With over 4400 patients, this is the largest study of patients with mec of the parotid gland. The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands. Rare locations include sinonasal tract and nasopharynx. Mucoepidermoid carcinoma is a type of cancer of the salivary glands. Greene flpage dlfleming id et al ajcc cancer staging manual. Mucoepidermoid carcinoma mec is a malignant epithelial neoplasm composed of varying proportions of mucous, epidermoid, intermediate, columnar, and clear cells and often demonstrates prominent cystic growth. Postoperative radiation therapy for parotid mucoepidermoid.
Epithelialmyoepithelial carcinoma of the parotid gland. Mucoepidermoid carcinoma is the most common parotid malignancy, with an incidence rate of 2. Mucoepidermoid carcinoma is the most common malignant tumor of salivary gland. Salivary gland neoplasm an overview sciencedirect topics. Role of intraparotid node metastasis in mucoepidermoid carcinoma. For highgrade mucoepidermoid carcinoma, radical parotidectomy is the treatment of choice nagarkar et al. Mucoepidermoid carcinoma mec is the most common malignant primary salivary gland tumor and is composed of a mixture of mucous, intermediate, and epidermoid squamoid cells. Mucoepidermoid carcinoma, or cancer of the salivary gland, is a genetic disease in the sense that it occurs due to changes mutations in genes that regulate how cells in the body divide. Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. Recurrent mucoepidermoid carcinoma of parotid with facial. It can also occur in other organs such as the thyroid, bronchi and lacrimal sac. Mucoepidermoid carcinoma involving warthin tumor a report of.
However, some of these tumors can also be cancerous malignant. It infiltrates the left parapharyngeal space, left eustachian tube, left fossa of rosenmuller as well as left longus capitis muscle. Mucoepidermoid carcinoma mec represents 5 to 12% of salivary gland tumors, with the most common site being the parotid gland 70 to 90%. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac, and thyroid gland mucicarmine staining is one stain used by pathologist for detection. Case report skeletal muscle and brain metastases arising. Salivary gland cancers are rare and represent approximately 5% of all head and neck cancers and only 0. Publications home of jama and the specialty journals of. The most common malignant salivary gland tumors include adenoid cystic carcinoma acc, mucoepidermoid carcinoma, secretory carcinomas, acinic cell carcinoma, and various adenocarcinoma histologies, including salivary ductal carcinoma. Additionally, the diagnosis of primary scc of the parotid gland. Health, general cancer diagnosis carcinoma hiv viruses hiv infection case studies complications and side effects hiv infections squamous cell carcinoma care and treatment causes of. Mucoepidermoid carcinoma mec is the most common malignant neoplasm of the major salivary glands, accounting for 15. Mucoepidermoid carcinoma was the most frequent of the pri. Pdf mucoepidermoid carcinoma mec is the most common malignant neoplasm of the major salivary glands, accounting for 15. This video clipping shows exision of mucoepidermoid carcinoma of parotid gland.
Mucoepidermoid carcinoma is the most common type of salivary gland cancer in adults. Imaging perineural invasion for parotid tumor facial nerve entire nerve should be assessed all the way even if there is no clinical facial paralysis auriculotemporal nerve through a small fat pad along the medial aspect of the lateral pterygoid muscle and just inferior to the foramen ovale. Mucoepidermoid carcinoma in a minor salivary gland in a child. The aim of this article is to report a case of mec in a 73yearsold male patient who presented with a painless firm fluctuant swelling in left preauricular area. We searched the computerized files of the department of. Lowgrade parotid mucoepidermoid carcinoma can be adequately treated by conservative parotidectomy. Mucoepidermoid carcinoma of the parotid gland in children. Mec also develops in various sites such as lung, thyroid, breast, skin, pancreas, esophagus, and cervix. Discussion the parotid tail is an anatomically challenging area to clinicians and radiologists. A rare case of mucoepidermoid carcinoma of parotid with. They are unencapsulated or poorly encapsulated and infiltrate surrounding tissue freely. Mucoepidermoid carcinoma of the right parotid gland occ.
To determine the presentation, pathologic features, treatment outcome, and prognosis of mucoepidermoid carcinoma of the parotid gland in children. An immunohistochemical panel for reliable differentiation. However, mucoepidermoid carcinoma is not inherited from a parent or passed down through a family. It accounts for pdf available in archives of medical science 1. The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma. Mucoepidermoid carcinoma is the most common salivary gland malignancy and is histologically comprised of a mixture of mucus cells, intermediate cells and squamoid or epidermoid cells. Mucoepidermoid carcinoma is the most common malignant sgt. Mucoepidermoid carcinoma mec is the epithelial salivary gland neoplasm of the oral cavity. Mucoepidermoid carcinoma presenting as a large cyst of the parotid gland in hiv disease.
Acute and chronic sialadenitis not responding to conservative treatment requires an appropriate surgical approach. Three patients had superimposed infection of underlying lesions. Circumscribed tumor, may not be attached to surface multilobulated nodulocystic tumor extending throughout dermis, exhibiting glandular and squamoid differentiation. Salivary gland cancer is diagnosed in 23 individuals per 100,000 people each year, and 3035% of these are mucoepidermoid carcinomas. Original article, case study by ear, nose and throat journal. Mucoepidermoid carcinoma with distant metastases to the kidney, adrenal gland, skull and gluteus maximus muscle. Recurrent mucoepidermoid carcinoma of parotid with facial tics report of an unusual case pirabu sakthivel, chirom amit singh, smriti panda, suresh chandra sharma, konki malla abhilash and milind sagar. Abnormal large mass at the region of the left parotid gland with heterogenous pattern of enhancement. Mucoepidermoid carcinoma presenting as a large cyst of the.
Mucoepidermoid carcinoma is the most common malignant salivary gland neoplasm in both adults and children. Approximately 80% of salivary gland tumors are considered benign, pleomorphic adenoma being the most common type. Gene expression profiling analysis of crtc1maml2 fusion. The surgical treatment varies with the tumor grade. Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. This is a patient with surgical stage t1, clinical n0, lowgrade parotid mucoepidermoid carcinoma. Major metastatic sites of salivary tumors are lung, bone and liver. Mucoepidermoid carcinoma the salivary glands are those glands whose primary function is to produce saliva. Although parotid gland carcinoma is the most common salivary gland tumor, primary squamous cell carcinoma scc of the parotid gland was rarely reported with aggressive biology behavior and high rate of lymph node metastasis. More than half of these cases involve the major salivary glands, primarily the parotid glands. Mucoepidermoid carcinoma is a type of cancer of the salivary glands salivary gland cancer is diagnosed in 23 individuals per 100,000 people each year, and 3035% of these are mucoepidermoid carcinomas. Mucoepidermoid carcinoma mec, one of the most common salivary gland malignancies, is rare in children. Mucoepidermoid carcinoma of the parotid karger publishers. Mucoepidermoid carcinoma genetic and rare diseases.
Lowgrade tumors present as a slowgrowing painless mass. Mucoepidermoid carcinoma with distant metastases to the. Clinical, histological, and radiological findings of palatal mec in a 12yearold girl are presented with threeyear followup. Cancer in the salivary gland is called salivary gland cancer. Mucoepidermoid carcinoma mec is the most common malignant form of salivary gland tumors. Majority of the salivary gland tumors arise in parotid gland with maximum. The most common minor salivary gland site is the palate. An analysis of all salivary gland lesions accessioned at the armed forces. In the face of small, lowgrade cancers, the risk of lymph. Mucoepidermoid carcinoma what is, treatment, survival. This tumor may also demonstrate clear cell, oncocytic or columnar cells. The lesion extends upwards and infiltrates the left infratemporal fosaa and both pterygoid muscles.
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